| ARTICLE ABSTRACT | |||||||
| DOI: 10.1099/vir.0.18942-0 | ||||||||
| Online 28 May 2003 | ||||||||
Department of Biochemistry, Purdue University, West
Lafayette, IN 47907-1153, USA
Vaccinia virus replication takes place in the cytoplasm of the host cell. The nearly 200 kbp genome owes part of its complexity to encoding most of the proteins involved in genome and mRNA synthesis. The multisubunit vaccinia virus RNA polymerase requires a separate set of virus-encoded proteins for the transcription of the early, intermediate and late classes of genes. Cell fractionation studies have provided evidence for a role for host cell proteins in the initiation and termination of vaccinia virus intermediate and late gene transcription. Vaccinia virus resembles nuclear DNA viruses in the integration of viral and host proteins for viral mRNA synthesis, yet is markedly less reliant on host proteins than its nuclear counterparts.
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This article is now available in the September 2003 print issue of JGV (vol. 84, 2293–2303). The complete issue of the journal may be seen in electronic form on JGV Online.
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