Fig. 2. Gene layout in representatives of the four adenovirus genera recognized. Each genome is represented by a central blue horizontal line marked at 5 kbp intervals. Protein-encoding regions are shown as arrows. Cyan denotes genus-common genes, other colours indicate related genus-specific genes (E1B 55K and E4 34K are related between the Mastadenovirus and Atadenovirus genera), and genus-specific genes that lack relatives are uncoloured. E1 and E4 are marked in all genera and E3 in the Mastadenovirus and Siadenovirus genera, and these regions are shaded violet. E2A and E2B genes are present in all genera, and these regions are indicated for the Mastadenovirus genus. Untranslated leader exons in the Mastadenovirus genus are shown for late, E2, E3 and E4 genes, with early transcripts in red, late transcripts in blue and 5´-terminal exons broader than internal exons. The VA RNA genes in the Mastadenovirus and Aviadenovirus genera are also included.

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